Intrathoracic esophageal replacement by in situ tissue-engineered esophagus
نویسندگان
چکیده
منابع مشابه
Circumferential Esophageal Replacement by a Tissue-engineered Substitute Using Mesenchymal Stem Cells
Tissue engineering appears promising as an alternative technique for esophageal replacement. Mesenchymal stem cells (MSCs) could be of interest for esophageal regeneration. Evaluation of the ability of an acellular matrix seeded with autologous MSCs to promote tissue remodeling toward an esophageal phenotype after circumferential replacement of the esophagus in a mini pig model. A 3 cm long cir...
متن کاملCircumferential esophageal replacement using a tube-shaped tissue-engineered substitute: An experimental study in minipigs.
BACKGROUND Esophageal replacement by the colon or the stomach for malignant and nonmalignant esophageal diseases exposes to significant morbidity and mortality. In this setting, tissue engineering seems to be a seductive alternative. METHODS In a porcine model, we performed a 5-cm-long circumferential replacement of the cervical esophagus by a tubulized acellular matrix (small intestinal subm...
متن کاملStem Cell‐Based Tissue‐Engineered Laryngeal Replacement
: Patients with laryngeal disorders may have severe morbidity relating to swallowing, vocalization, and respiratory function, for which conventional therapies are suboptimal. A tissue-engineered approach would aim to restore the vocal folds and maintain respiratory function while limiting the extent of scarring in the regenerated tissue. Under Good Laboratory Practice conditions, we decellulari...
متن کاملTissue Engineered Scaffolds in Regenerative Medicine
Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissu...
متن کاملFunctional testing of a tissue-engineered vocal fold cover replacement.
OBJECTIVES Tissue engineering may provide a treatment for severe vocal fold scars. This study quantifies mechanical properties and demonstrates vibration of a tissue-engineered vocal fold cover replacement. METHODS Tissue-engineered constructs were produced from fibrin and adipose-derived stem cells. Optimized bilayered constructs contained epithelial and mesenchymal cell phenotypes in a stra...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2008
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2008.05.027